Testosterone injections can sometimes cause side effects that resemble flu-like symptoms such as fever, chills, body aches, and fatigue. While not extremely common, some men do report these types of reactions, especially early on in treatment.
The most likely culprits behind these flu-like side effects include:
- Immune system activation - Testosterone stimulates the immune system, which could trigger inflammatory responses manifesting as flu-like discomforts. This reaction tends to be temporary.
- Response to carrier oil - Many testosterone preparations are suspended in cottonseed oil or sesame oil. For some, these carrier oils can cause allergic reactions or side effects. Switching to a different carrier oil may help.
- Hormone fluctuations - Rapid rises or peaks in testosterone levels can also initiate temporary symptoms in some such as chills, fatigue, and muscle aches. This usually stabilizes within the first weeks of therapy as the body adjusts.
- Underlying conditions - Pre-existing immune or inflammatory issues may make someone more prone to flu-like reactions when introducing new medications like testosterone.
If flu-like symptoms are bothersome, there are some things to try:
- Wait it out - Give your body 1-2 months to adjust to the swings in hormones. Side effects often resolve on their own.
- Lower the dose - Temporarily reducing the dosage can sometimes minimize side effects.
- Change injection frequency - Injecting smaller doses more frequently (e.g. every 3 days instead of weekly) may reduce peaks and troughs.
- Try different oils - Changing to a testosterone preparation that uses a different carrier oil (sesame, cottonseed, or ethyl oleate) may help if you suspect oil reactions.
- Evaluate medications - Review any other new medications with your healthcare provider to identify potential interactions.
- Assess for illnesses - Rule out viral infections, autoimmune issues, or other conditions that could cause similar symptoms.
The Renewal Hormone Center has extensive experience managing testosterone therapy side effects. Our physicians will collaborate with you to pinpoint the root cause and adjust your treatment protocol to maximize benefits while minimizing discomfort. We offer state-of-the-art testing, premium injectables, and cutting-edge therapies to help you feel your best. Reach out today to learn more or schedule a consultation!
I hope this gives you a better understanding around testosterone injections and potential flu-like side effects. Please let me know if you have any other questions!